Progress In Medicinal Chemistry, Volume 41

Progress In Medicinal Chemistry, Volume 41

Author: F.D. King, A.W. Oxford

Format: Hardcover

Pages: 300

ISBN: 9780444511423

Language: English

Publisher: JAI Press(NY)

Release Date: January 01, 2003

Description du Livre

This series has a long established reputation for excellent coverage of almost every facet of medicinal chemistry. DESCRIPTION: The Progress in Medicinal Chemistry series is a respected and instructive source of information on the subject. It has a long established reputation for excellent coverage of almost every facet of medicinal chemistry. This volume features a comprehensive account of in vitro and in vivo models and in silico approaches for the prediction of oral absorption and bioavailability. Also discussed is the virtual screening of virtual libraries as a means of identifying lead molecules for drug discovery programs. Includes a thorough review of inhibitors of phosphodiesterase 5 (PDE5) including compounds that have been recently advanced into clinical trials. TABLE OF CONTENTS: Predicting Oral Absorption and Bioavailability; Virtual Screening of Virtual Libraries; γ -Secretase Inhibitors-From Molecular Probes to New Therapeutics; The Discovery and Development of 5-HT terminal Autoreceptor Antagonists; Orally Bioavailable β 3-Adrenergic Agonists as Potential Therapeutic Agents for Obesity and Type II Diabetes; Antagonists of the Corticotropin Releasing Factor Receptor; Phosphodiesterase Type 5 (PDE5) Inhibitors.

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